PMPred is an integrative framework for pathogenicity evaluation of protein sequences after alteration. To predict the pathogenic effect of mutations, PMPred measures the significance of changes between molecular functions of the wildtype and altered sequences. PMPred provides the statistical measurement scores with domain analysis results and considers the variant's distance from N-terminus to assist with better data interpretation.
Please submit nonsense/indel variants as a VCF file. The first five space or tab delimited fields are Chr, Start, End, Ref, Alt. The rest of the columns are completely optional. The supported genome build is GRCh37/hg19. Variants will be processed more quickly if you upload them in smaller batches. The results will be sent to you in CSV format via email.